We have recently shown that the beneficial effect of WWL70 in the mouse model of traumatic brain injury [22] is at least in part due to its activation of CB1 and CB2 receptors, whereas in the experimental autoimmune encephalomyelitis mouse model, the therapeutic effect of WWL70 is chiefly mediated by the activation of CB2 receptors, as assessed by the use of the selective CB2 receptor antagonist and the CB2 receptor knockout mice [23]. Here, CNR1 is linked to experimental autoimmune encephalomyelitis.