We found that 3% sevoflurane anesthesia for 2 h increased the levels of TNF-α, IL-1β, and IL-6 in the hippocampus after anesthesia in both normal and MS rats, but the degree of pro-inflammatory cytokines increase in MS rats was markedly higher than that in normal rats after anesthesia (Fig. 2). The gene discussed is TNF; the disease is myeloid sarcoma.