In the current study, we found that sevoflurane anesthesia activated hippocampal NF-κB signaling both in MS rats and normal rats, but the levels of nuclear NF-κB p65 protein and the fluorescence intensity of p-NF-κB p65 in the hippocampus in MS rats were significantly higher than those in normal rats (Figs. 2 and 3). This evidence concerns the gene NFKB1 and myeloid sarcoma.