Significantly, while CRNDE knockdown led to significantly inhibited CRC cell proliferation, simultaneous miR-181a-5p knockdown completely reversed the inhibition of cell proliferation (Fig. 6a), indicating that the increased levels of miR-181a-5p expression were essential for the cell proliferation inhibition induced by CRNDE knockdown. This evidence concerns the gene CRNDE and colorectal carcinoma.