In addition, CRNDE knockdown inhibited the activity of Wnt/β-catenin signaling, as evidenced by TOP/FOP luciferase activity, but this inhibition was abolished by simultaneous miR-181a-5p knockdown (Fig. 6f and Additional file 7f), suggesting that CRNDE regulated Wnt/β-catenin signaling in CRC cells via modulating the expression of miR-181a-5p. Here, CRNDE is linked to colorectal carcinoma.