INS and type 2 diabetes mellitus: Oguri and colleagues [143] demonstrated a significant increase of systemic glucose uptake in T2DM individuals and enhanced GLUT-4 membrane translocation in individuals after a single bout of moderate-intensity exercise Collectively, the evidence in the literature advocates that diabetic pharmacotherapy alone does not reduce the risks of cardiovascular events; rather the addition of routine physical exercise can synergise with the treatment through the improvement of insulin sensitivity and enhancement of glucose utilization.