NOTCH1 and colorectal carcinoma: However, it has been shown that the Mastermind-like 1 co-activator of Notch pathway can bind to the promoters of Cyclin D1 and Myc in colon cancer cell lines [52] and these molecules are activated directly by Notch1 in other types of cancer [53–57] and possibly by Cyclin D1 in CRC [58].