Thus, we set out to characterize the expression pattern of Dll4 and other Notch members in the ApcMin/+ tumors relatively to the normal intestine and compare endothelial-specific with ubiquitous Dll4 loss-of-function mutants to address the role of Dll4 in intestinal tumor development in the ApcMin/+ model. The gene discussed is DLL4; the disease is intestinal neoplasm.