AP2S1 and adenocarcinoma: To compare caspase-3 activity induced by PB28, PB221, PB183, F281 and PB282, Panc02 mouse adenocarcinoma cells were treated with sigma-2 ligands (200 μM) for 5 h and assayed for cleavage of the proluminescent caspase-3 substrate and subsequent generation of a glow-type luminescent signal.