Based on KEGG database, the 1167 DEGs were involved in 99 signal pathways, including cell cycle, oocyte meiosis, oocyte maturation mediated by progesterone, pathways in cancer, p53 signaling pathways, production of phagosome, metabolism of fatty acid, cytokines-cell factor receptor interactions, prion diseases, etc. (Table 3). This evidence concerns the gene TP53 and prion disease.