Here, we focused on the role of ARMS2 in AMD pathophysiology and aimed at defining the functional consequences of the AMD associated polymorphism (rs10490924) in ARMS2. Our findings demonstrate ARMS2 expression in human monocytes and microglia cells and suggest that ARMS2 functions are directly linked to the complement system, thereby mediating the opsonization of apoptotic and necrotic cells. Here, ARMS2 is linked to age-related macular degeneration.