SERPINE1 and obesity due to melanocortin 4 receptor deficiency: Considering this fact, in subgroup stratified analysis, the 4G/4G genotype has been shown to be associated with obesity under the dominant genetic model to be in concordance with Mertens et al. [72], who found increased PAI-1 levels are associated with increased visceral obesity due to its production by ectopic fat depots [73].