Patients were clustered into two groups showing more effect of traditional risk factors than genes; P1 group was mostly affected by dyslipidemia, LDL, total triglyceride, total cholesterol, smoking, and hypertension, with little contributing effect of gene variants (HPA-1, ACE, ApoE, and MTHFR1), while P2 cluster was mostly affected by their fasting blood sugar levels and ApoE variant. This evidence concerns the gene HPSE and metabolic syndrome.