Although there are no conclusive data available that associate the R2 haplotype per se with a relevant increased risk of thrombosis (i.e. taken in consideration that FV: Leiden frequency was comparable between CAD patient and control groups in the current study), it was observed previously that male carriers of the FV: R2 polymorphism, have increased circulating levels of FVIII [51]. Here, F8 is linked to coronary artery disorder.