F2 and hyperhomocysteinemia: Similar to our results, when Almawi et al. [55] studied FV 1691 G > A, PT 20210 G > A, and MTHFR 677 C > T gene variants in angiographically documented CAD, they found a strong association of hyperhomocysteinemia and homozygosity of the MTHFR 677 C > T, but not FV: Leiden or PT 20210 G > A mutations with CAD.