This variant showed significantly higher susceptibility for CAD under homozygote and allelic models and it was one of the most effective associated gene variants in combination with other variants for clustering our CAD patients by multivariate analysis (i.e. the combined occurrence of the MTHFR 677TT, ACE DD and FVR 4070AG genotypes seems to magnify the CAD risk in our population). The gene discussed is ACE; the disease is coronary artery disorder.