A recent report has identified that another new benzimidazole acridine derivative, N-{(1H-benzo[d]imidazol-2-yl)methyl}-2-butylacridin-9-amine, can induce apoptosis via the ROS-JNK signaling pathway in human colorectal cancer cell lines [34]. Here, MAPK8 is linked to colorectal cancer.