GADD45A and chronic myelogenous leukemia, BCR-ABL1 positive: To assess this, Lineage (Lin) negative spleen cells from CML mice were labeled with stem cell markers Sca and Kit, and it was observed that the percentage of GFP+Lin-cKit+Sca+ (LSK) cells in the Gadd45a deficient BCR-ABL expressing mice were significantly increased compared to WT/BCR-ABL mice (Figure 4A).