It is shown that hyperactivation of key signaling pathways, including the PI3k/AKT, Stat5 and p38 pathways, and expression of short transforming isoform of Cebpa in Gadd45a deficient BM cells may partly account for accelerated CML progression (Figure 6). This evidence concerns the gene GADD45A and chronic myelogenous leukemia, BCR-ABL1 positive.