In the subgroup analysis, the GLUT-1 positive expression was significantly correlated with the poor outcome of pancreatic cancer (HR=1.96, 95%CI=1.24-3.09, heterogeneity p=0.423) (Supplementary Figure 1) and gastric cancer (HR=1.48, 95%CI=1.13-1.93, heterogeneity p=0.529) (Supplementary Figure 2), while an evidently positive relation was detected in colorectal cancer patients (HR=0.37, 95%CI=0.23-0.60) (Supplementary Figure 3). This evidence concerns the gene SLC2A1 and familial pancreatic carcinoma.