The rs9388451 SNP is a non-coding SNP and near the HEY2 gene and encodes a basic helix-loop-helix transcriptional repressor that is expressed in the cardiovascular system.[35] Recently, the rs9388451 SNP was shown to be associated with Brugada syndrome and data indicates that HEY2 regulates cardiac electrical activity in Brugada syndrome by altering the transcriptional programming during cardiac development.[13] Even though the association of the (C/C) rs9388451 was not significant (OR = 1.50; P = 0.070), it showed the same trend and it could be due to lack of power in our analysis. Here, HEY2 is linked to Brugada syndrome.