CCNE1 and breast cancer: Also, genetic abnormalities associated with increased proliferation in breast cancer such as TNBC tumors, higher grade, higher expression of cell cycle regulatory proteins such as cyclin E, and increased incidence of mutations in tumor suppressor genes such as p53, RASSF1A, RARβ, and HIN-1 are known to accelerate the development of breast tumors and are more prevalent among AA compared to EA [14].