10-NCP-induced autophagy did not lead to the increase in the axonal AV density of AD neurons overexpressing Snapin (AVs per 100 μm length: 4.71 ± 0.31; p<1×10−11) as a result of enhanced retrograde transport (10-NCP treated hAPP neurons: 11.3% ± 1.19%; hAPP neurons expressing Snapin: 43.57% ± 3.4%, p<1×10−8) (Figure 7—figure supplement 1D,E). The gene discussed is SNAPIN; the disease is Alzheimer disease.