AD mouse brains displayed significantly increases of the synaptosomal preparations (Syn)/post-nuclear supernatants (PNS) ratio in APP (1.36 ± 0.03; p=0.007319), p62 (1.17 ± 0.02; p=0.021517), and LC3-II (4.2 ± 0.57; p=0.011328), but not SYP (1.02 ± 0.07; p=0.73211) relative to those of WT littermates. The gene discussed is APP; the disease is Alzheimer disease.