TGFB1 and colorectal carcinoma: The WNT (Vermeulen et al., 2010), PI3K (Tenbaum et al., 2012), BMP/TGF‐beta (Lombardo et al., 2011) signalling pathways all affect self‐renewal and differentiation capacity of CRC stem cells, and thus, mutations in these pathways likely regulate the frequency of CRC‐SCs.