HIF1A and hypopharynx cancer: In head‐and‐neck cell lines, TWIST1 was found to be an essential downstream target of HIF‐1α and that knockdown of TWIST1 led to a decreased number of metastatic nodules after either tail vein injection or orthotopic transplantation of hypopharyngeal cancer cell line with overexpression of HIF‐1α (Yang et al., 2008).