Further supporting the notion that TWIST1 promotes EMT and tumor invasion is the finding that deletion of one allele of TWIST1 gene completely blocked the conversion from benign papilloma to invasive squamous cell carcinoma in the combined and 12‐O‐tetradecanoylphorbol‐13‐acetate (DMBA/TPA) skin tumor model (Beck et al., 2015). This evidence concerns the gene TWIST1 and skin neoplasm.