EGFR and cancer: Moreover, NHERF1 has also been shown to interact with cancer-related proteins such as phosphatase and tensin homolog deleted on chromosome ten (PTEN), spleen tyrosine kinase (SYK), platelet-derived growth factor receptor (PDGFR), and epidermal growth factor receptor (EGFR), and modulate their downstream signaling [7,8,9,10].