The subcutaneous xenografts of Shp2-knockdown ESCC cells exhibited an elevated growth tendency and a larger tumor size than the control ESCC cells (0.64 ± 0.65 g versus 2.25 ± 1.34 g, p = 0.042; Figure 2D–F), indicating the suppressive effect of Shp2 on proliferation of ESCC cells in vivo. Here, PTPN11 is linked to neoplasm.