Moreover, Shp2 depletion led to overexpression of ABCG2 and Nanog, responsible for drug-resistance phenotype in ESCC cells (2.05 ± 0.61-folds, p = 0.042; 1.87 ± 0.31-folds, p = 0.041, Figure 4B). Here, PTPN11 is linked to esophageal squamous cell carcinoma.