On the contrary, Bard-Chapeau et al. found that hepatocyte-specific Shp2 knockout led to the development of hepatocellular cancer (HCC) in mice via activation of Stat3 (signal transducer and activator of transcription 3), implying a tumor-suppressing role of Shp2 [20]. Here, PTPN11 is linked to hepatocellular carcinoma.