Cyclin D1 and Survivin, downstream molecules of Stat3, were upregulated (1.18 ± 0.01-folds, p < 0.001; 1.49 ± 0.18-folds, p < 0.01) upon Shp2 depletion in ESCC cells, while Cyclin D2 and c-Jun expression were attenuated (0.28 ± 0.14-fold, p < 0.001; 0.29 ± 0.14-fold, p < 0.001; Figure 3E). This evidence concerns the gene CCND2 and esophageal squamous cell carcinoma.