We found that the expression of TLR-3 induced by PR8 (at 24 h post-infection) was markedly impaired by treatment with R. isatidis polysaccharides at higher doses (30 mg/mL or 15 mg/mL) but not at a lower dose (7.5 mg/mL), indicating dose-dependent inhibition (Figure 3). Here, TLR3 is linked to infection.