CCL5 and infection: Furthermore, at 24 h post-infection, R. isatidis polysaccharides also significantly inhibited the mRNA expression of IL-6 (p < 0.05), CCL-5 (p < 0.01), and especially MIG (p < 0.001), compared with the upregulated expression of all of the tested pro-inflammatory cytokines/chemokines in the PR8-infected cells at a dose of 30–7.5 mg/mL, and it is only has a significant inhibition efficacy in a 30 mg/mL dose for the mRNA expression of IP-10 (p < 0.05) (Figure 1C).