As our understanding of AR biology has improved, it has become apparent that the AR-signaling pathway can interact with a number of additional oncogenic signaling pathways, including those involved in promoting growth and resistance across a variety of tumor types (e.g., AKT/mTOR/PI3K, EGFR, HER2/Neu, Wnt) [5,6,7,8,9,10,11,12]. This evidence concerns the gene AR and neoplasm.