As examples, TGFβ deregulation has been implicated in metaplastic SM formation within malformed kidneys (Yang et al., 2000), aberrant ECM modelling within aortic aneurysms in Marfan syndrome (Nataatmadja et al., 2006) and the formation of fibrotic strictures in Crohn's disease (Li et al., 2015). The gene discussed is TGFB1; the disease is aortic aneurysm.