Furthermore, based on the similarities between neuropathological and biochemical features of 129MM mice infected with the V2 PrPSc strain and those seen in one type of dural graft iCJD, it has been suggested that the combination of PRNP 129MM genotype, kuru plaques, and a specific PrPSc biochemical pattern may indicate an acquired aetiology of CJD [91–93]. Here, PRNP is linked to Creutzfeldt Jacob disease.