KLF8 and cancer: Moreover, we have previously reported similarly high frequencies of cancer-specific promoter hypermethylation for the eight biomarker candidate genes AOX1 (Aldehyde Oxidase 1), CCDC181 (Coiled-Coil Domain Containing 181, also known as C1orf114), GABRE (Gamma-Aminobutyric Acid A Receptor Epsilon), GAS6 (Growth Arrest-Specific 6), HAPLN3 (Hyaluronan and Proteoglycan Link Protein 3), KLF8 (Kruppel-like Factor 8), MOB3B (MOB kinase activator 3B), and SLC18A2 (Solute Carrier Family 18 vesicular monoamine Member 2) in malignant tissue samples from radical prostatectomy (RP) specimens20, 21, 22, 23.