Moreover, we have previously reported similarly high frequencies of cancer-specific promoter hypermethylation for the eight biomarker candidate genes AOX1 (Aldehyde Oxidase 1), CCDC181 (Coiled-Coil Domain Containing 181, also known as C1orf114), GABRE (Gamma-Aminobutyric Acid A Receptor Epsilon), GAS6 (Growth Arrest-Specific 6), HAPLN3 (Hyaluronan and Proteoglycan Link Protein 3), KLF8 (Kruppel-like Factor 8), MOB3B (MOB kinase activator 3B), and SLC18A2 (Solute Carrier Family 18 vesicular monoamine Member 2) in malignant tissue samples from radical prostatectomy (RP) specimens20, 21, 22, 23. This evidence concerns the gene HAPLN3 and cancer.