In PDE3B KO mice, changes in adiponectin as well as the increase in insulin secretion in response to glucose, glucagon-like peptide1 and CL31, and the presence of smaller adipocytes and gonadal fat depots, as well as enhanced energy dissipation, might represent additional mechanisms that maintain or improve sensitivity to insulin, and/or prevent more marked insulin resistance and glucose intolerance. Here, PDE3B is linked to Insulin resistance.