Gliosis derived from activation and proliferation of microglia and astrocytes of 16-week-old Hexb−/− mice could be reduced by suppressing autoantibody-mediated immune responses by deleting Fcrγ. Thus, to determine the time of gliosis, activation states of microglia and astrocytes were analyzed at 2–4 weeks of age by immunostaining. The gene discussed is FCER1G; the disease is Gliosis.