MAOB and Parkinson disease: For example, safinamide, a MAO B selective reversible inhibitor most recently approved as first add-on treatment of Parkinson’s disease, is active in submicromolar concentration ranges (IC50 = 0.048–0.112 μM for hMAO B; IC50, MAO B/IC50, MAO A < 0.00120, 21, 22).