IGHE and Increased total eosinophil count: These include: Omenn syndrome (OS), characterized by erythroderma, lymphadenopathy, eosinophilia, increased serum IgE levels, and the presence of oligoclonal T cells; “leaky” SCID, with varying numbers of T and B cells but without the typical features of OS; SCID with expansion of γδ T lymphocytes; delayed-onset combined immune deficiency with granuloma and/or autoimmunity; and in a single case of idiopathic CD4+ T-cell lymphopenia, presenting with extensive chickenpox and recurrent pneumonia (Ijspeert et al. 2014; Kuijpers et al. 2011; Lee et al. 2014; Niehues et al. 2010; Omenn 1965).