Effects of IMiDs in MM cells are pleiotropic, causing, among others, decrease in expression of anti-apoptotic factor Bcl2, G0/G1 arrest through p21WAF−1 up-regulation, and down-regulation of interferon regulatory factor 4 (IRF4) (Lopez-Girona et al. 2012). The gene discussed is IRF4; the disease is Miyoshi myopathy.