Interestingly, after stratifying patients according to the IL6 gene C-174 gene polymorphism genotypes, we have shown that higher baseline depressive symptom severity measured by MADRS and BDI predicted higher risk of depression in the course of antiviral treatment in G only allele carriers (patients with GC and GG genotype) (p = 0.004, p = 0.00008, respectively; Table 4). Here, IL6 is linked to major depressive disorder.