IFNA1 and Mental deterioration: Interferon (IFN)-α is the main pharmacological treatment for chronic hepatitis C virus (HCV) infection, because of its potent antiviral, antiproliferation and immunomodulatory properties (Lamers et al. 2012); however, at the same time IFN-α is known to induce several neuropsychiatric side effects, including anorexia, fatigue, lethargy, loss of interest, lack of concentration, irritability, cognitive decline, emotional lability and social withdrawal (Cattie et al. 2014).