This finding is consistent with the evidence that plasma IL-6 positively is associated with depressive symptoms among patients without any immune-modulatory treatment (Liu et al. 2012) as well as among patients during IFN-α treatment (Bonaccorso et al. 2001; Prather et al. 2009; Wichers et al. 2007) including CHC patients (Udina et al. 2012). This evidence concerns the gene IL6 and cryohydrocytosis.