In patients with B-CLL, they have shown a decreased gene expression of TLR2 and TLR4 and an increased gene expression of TLR7, TLR9 and TLR10 (Grandjenette et al. 2007; Muzio et al. 2009; Spaner et al. 2006). The gene discussed is TLR4; the disease is B-cell chronic lymphocytic leukemia.