To investigate the involvement of PI3K/Akt and p70S6K in the modulation of SREBP-1c and NLRP3 expression by HGPg infection, HGFs were incubated with specific inhibitors for PI3K/Akt (LY294002) and p70S6K (rapamycin) for 1 h before and during infection with HGPg. The gene discussed is NLRP3; the disease is infection.