The overexpression of PEMT in CBRH-7919 rat hepatoma cells resulted in a downmodulation of the PI3K/Akt signaling pathway, which was evident by reduced protein levels of c-Met, PDGF receptor, PI3K, Akt, and Bcl-2, in addition to decreased phosphorylation of Akt Thr308, which was accompanied by elevated cell apoptosis (179). Here, AKT1 is linked to hepatocellular carcinoma.