Further, overexpression of eIF4E leads to increased expression of a subset of proteins, influencing angiogenesis and tumor progression (VEGF and fibroblast growth factor-2 (FGF-2)), growth stimulation (platelet-derived growth factor), prosurvival (Bcl-2 and Bcl-xL), cell-cycle progression (c-myc, cyclin D1, and ornithine decarboxylase), epithelial-to-mesenchymal transition (SNAIL and MMP), and invasion (integrin β1) [134, 137, 139–142]. This evidence concerns the gene VEGFA and neoplasm.