Some studies have reported that B7-H3 high expression in CRC patients are associated with lymph node metastasis and prognosis value,18,22,23 while the other studies report contrary findings.19,20,21 To derive the precise relationship between B7-H3 expression and clinical prognosis in CRC patients, a meta-analysis of six independent studies based on a total of 1,202 CRC patients was performed, to see the relationship between B7-H3 expression and CRC prognosis.24-26. Here, CD276 is linked to metastatic malignant neoplasm in the lymph nodes.