High expression of B7-H3 strengthened the resistance to chemotherapeutics and anti-apoptotic ability, nevertheless knockdown of B7-H3 might enhance the sensitivity of apoptosis induced by drug.34-37 Up to now, many studies had reported that the high-expression of B7-H3 significantly correlated with lymphatic metastasis and lymphangiogenesis in CRC.18,22,23 However, other reports did not prove such relationship, or opposite correlations were found.19,20,21 To date, there is no agreement on relationship between high-expression of B7-H3 detected by immunochemistry and survival in CRC patients. This evidence concerns the gene CD276 and colorectal carcinoma.