Some researchers suggest that the B7-H3 signaling system is one of efficient pathway in regulating lymphangiogenesis.5,6,16 B7-H3 may show resistance to apoptosis via the signaling pathway of Jak2-STAT3, and facilitates vessel enlargement into the surrounding lymphatic vessels.17 Previous epidemiological studies have showed that B7-H3 over expression was correlated with lymphatic metastasis in CRC.18-23 However, the results remain inconclusive. The gene discussed is CD276; the disease is colorectal carcinoma.