CRP and breast cancer: It has also been asserted that hormones of metabolism (in the leptin family), inflammatory mediators (C-reactive protein (CRP), adiponectin, prostaglandins), depressed immune system functioning (T helper cells, leukocytes, NK cells) and reactive oxygen species (ROS) explain the reason that obese women who have breast cancer diagnosis have a more negative outcome compared to their slimmer counterparts.7