LACTB and Neonatal sepsis: The carbapenems, sulbactam and amikacin are used to treat neonatal sepsis caused by AmpC producing strains but if mutations occur in organisms, they can become resistant to carbapenems as well.1 Boronic acid can be used as AmpC beta-lactamase inhibitor.4 Multidrug resistance can be avoided by the restricted use of third-generation cephalosporins in neonatal sepsis.6