The genome wide association studies have identified various susceptibility genes, including several type 2 diabetes mellitus (T2DM) such as PPARG, TCF7L2, FTO, CDKN2A/2B, and IRS1 etc. to be associated with the risk of T2DM, though their definite relation with GDM remains to be explored further.6,7. This evidence concerns the gene IRS1 and type 2 diabetes mellitus.