An increase of NK cell frequency has been observed within the tumor-invaded lymph nodes (TILNs) of advanced stages melanoma patients, with a prevalence of the CD56dim NK cell subpopulation characterized by a high expression of CD57, KIRs, CD69, and the homing chemokine receptor CCR7, suggesting overall a more differentiated effector phenotype actively migrating in the TILNs. Here, CCR7 is linked to melanoma.