WNT5A and obesity due to melanocortin 4 receptor deficiency: During the last 10 years, an increased Wnt5a expression was observed in a variety of inflammatory disease settings such as skin lesions of patients with psoriasis vulgaris (54) or cutaneous lichen planus (55), obesity-induced adipose tissue inflammation (56, 57), atherosclerotic lesions (58), and in the sera of patients with septic shock (59).