Previous studies have reported that overexpression of p75NTR in primary cortical neurons, PC12 cells, or glioma cells leads to the activation of both JNK kinase and apoptotic Caspase-3 (Gu et al., 1999; Wang et al., 2001; Harrington et al., 2002; Bhakar et al., 2003). This evidence concerns the gene CASP3 and central nervous system cancer.