In summary, we have been able to reproduce in human iPSC derived MN some crucial pathological hallmarks seen in ALS such as (I) the cytoplasmic FUS mislocalization, (II) the formation of FUS+ inclusions (Japtok et al., 2015; Lenzi et al., 2015; Ichiyanagi et al., 2016) as well as (III) an increased DNA damage in MN (Wang et al., 2013; Qiu et al., 2014). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.