If the functions of Igfn1 and Krt18 are unknown in neurons, their function in smooth muscle cells (Baker et al., 2010) and implication in intracerebral arteriovenous malformations (Sasahara et al., 2007) indicate that hypergravity could act on pericytes to modify the cerebrovascular function and hippocampus perfusion. Here, IGFN1 is linked to arteriovenous hemangioma/malformation.