The NASH group had 10- and 5-fold increased serum alanine aminotransferase and aspartate aminotransferase levels, and both HFD and HFD+STZ groups had a 4- and 6-fold increased HOMA-IR levels, respectively (P<0.05; Table 1). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.