In MDA-MB-231 and MCF-7-Ras breast cancer cells, which have more stem-like properties, AKT1 inhibition has a more prominent effect than AKT2 inhibition in reducing the cancer cell stem phenotype, as reflected by reduced mesenchymal-epithelial transition (MET) and expression of epithelial-like markers [80]. The gene discussed is AKT1; the disease is breast cancer.