In contrast, hepatic Akt1 knockout in an Akt2-null murine model triggers a FOXO-dependent inflammatory response leading to spontaneous HCC, which was not observed with hepatic knockout of Akt1 or Akt2 alone, suggesting a novel co-operative and potentially tumour-suppressive effect of AKT1/2 in hepatic tissue [66]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.