shRNA knockdown of INPP4B in MCF-7 and ZR-75-1 breast cancer cells, which express high levels of SGK3, reduced anchorage-independent cell growth, cell migration, 3D colony formation and mouse xenograft tumour growth as well as inhibiting IGF-1-stimulated SGK3 phosphorylation (Table 2) [144]. The gene discussed is INPP4B; the disease is breast carcinoma.