In vitro studies in breast cancer cell lines suggest that AKT1-mediated degradation of the pro-invasion transcription factor NFAT and the tumour-suppressor tuberous sclerosis complex 2 (TSC2) decreases, whereas AKT2-mediated up-regulation of pro-invasive β1-integrin promotes cell migration [22,23,74]. Here, AKT2 is linked to breast carcinoma.