Colonies that formed under anchorage-independent cell growth conditions in INPP4B/PTEN knockdown cells were larger than INPP4B or PTEN single knockdown colonies, suggesting that depletion of both INPP4B and PTEN can enhance cell growth in rare events in a manner similar to dual PTEN/PIPP knockdown in melanoma cell lines [107,121]. The gene discussed is INPP5J; the disease is melanoma.