In PC-3 prostate cancer cells, siRNA-mediated knockdown of AKT1 inhibited cell migration and cell adhesion, whereas AKT2 knockdown promoted cell migration suggesting that AKT1 has a pro- and AKT2 has an antimigratory role in prostate cancer, in contrast with their functions in breast cancer [78]. The gene discussed is AKT1; the disease is Familial prostate cancer.