INPP4B but not PTEN co-localizes with AKT2 and PIK3C2α on early endosomes of thyroid cancer cells where INPP4B negatively regulates PIK3C2α-mediated AKT2 signalling through PtdIns(3,4)P2 hydrolysis [134]. The gene discussed is INPP4B; the disease is thyroid cancer.