In contrast, induction of AKT2 but not AKT1 silencing after 1 week caused widespread apoptosis and compromised cell morphology leading to complete disruption of spheroid architecture, which was recapitulated upon treatment of spheroids with an AKT2-specific inhibitor, suggesting that AKT2 plays a dominant role in 3D tumour survival and progression (Table 2) [100]. This evidence concerns the gene AKT1 and neoplasm.