SCN2A encodes the alpha2 subunit of the neuronal sodium channel and has also been associated with a wide phenotypic spectrum of epilepsy syndromes ranging from benign familial neonatal-infantile seizures to epilepsy of infancy with migrating focal seizures or other severe epileptic encephalopathies [117], [118], [119]. This evidence concerns the gene SCN2A and Epileptic encephalopathy.