Moreover, when including all three mental well-being parameters into one statistical model as independent variables with the log-transformed CRP level as the dependent variable, apathy (β = 0.082, p < 0.001) was the only significant correlate, whereas dispositional optimism (p = 0.40) and the 12-item GDS depression score (p = 0.36) were not. The gene discussed is CRP; the disease is major depressive disorder.