Although each of the major proteins in the m6A methylation complex—that is, RBM15, WTAP, METTL3, and METTL14—show alterations in myeloid leukemias, definitive demonstration of the role of m6A will require mechanistic evidence linking m6A alterations to leukemia phenotypes in these cancers. The gene discussed is METTL3; the disease is myeloid leukemia.