Modulation of lipogenic genes or proteins such as ATP citrate lyase (ACLY) [9], acetyl-coA carboxylase (ACC) [10–12] and fatty acid synthase (FASN) [13,14] either by chemical inhibitors or by RNAi-mediated gene silencing studies have been successful in demonstrating decreased cell proliferation and increased apoptosis in cancer models both in vitro and in vivo. The gene discussed is ACACA; the disease is cancer.