ENAH polymorphisms may thus affect the integrin-mediated APC-T cell adhesion component of the TCR activation process: there were six associated SNPs with pi < 10−3 in the coding region of ENAH (S8 Fig) in T1D with the strongest association by rs2639703 (pi = 1.2×10−5). This evidence concerns the gene ENAH and type 1 diabetes mellitus.